Buy O-Desmethyl-cis-tramadol online

Buy O-Desmethyl-cis-tramadol online

O-Desmethyl-cis-tramadol is an active metabolite of tramadol, a pain reliever often prescribed for moderate to severe pain. It plays a crucial role in the effectiveness of tramadol by interacting with the body’s opioid receptors. Buy O-Desmethyl-cis-tramadol online

Chemical Structure and Properties

Understanding the chemical makeup of O-Desmethyl-cis-tramadol helps us appreciate how it works. Here’s a look at its structure:

Chemical Formula: C15H23NO2

The structure includes a phenolic hydroxyl group that sets it apart from tramadol.

Pharmacodynamics and Mechanism of Action

How Does O-Desmethyltramadol Work?

O-Desmethyl-cis-tramadol binds to opioid receptors in the central nervous system. This binding:

• Inhibits ascending pain pathways.
• Modulates neurotransmitter release.
• Results in pain relief. Etonitazepipne for sale UK

O-Desmethyltramadol works by binding to the mu-opioid receptors, which blocks the transmission of pain signals.

Thermodynamic Properties.

O-Desmethyl-cis-tramadol is characterized with the standard Gibbs free energy of formation (ΔfG°) equal to = 18. 42 kJ/mol. This positive ΔG° value suggests that the formation of this compound from its constituent elements is a non-spontaneous process under standard conditions.

In this case, the symbol ΔfH° represents the standard enthalpy of formation in the gas phase and is equal to -329 pending any changes if ever the conditions are altered. 19 kJ/mol. A negative sign on the heat of formation shows that the formation of O-Desmethyl-cis-tramadol from its elements is exothermic and heat is released to the surroundings.

Phase Change Enthalpies.

The enthalpy of fusion (ΔfusH°) for O-Desmethyl-cis-tramadol is 28Selection of data. 15 kJ/mol. This value also denotes the heat energy that is needed to change the compound from a solid state to a liquid state at the melting point.

The enthalpy of vaporization (ΔvapH°) is 81kcal mol^(-1). Actually, the energy value of 96 kJ/mol represents the amount of energy that takes place in converting the liquid phase of the given compound into the gaseous phase at the boiling point.

Solubility and Partition Coefficient.

With anticipating the reader with information about water solubility, we turn to O-Desmethyl-cis-tramadol and find that its logarithm for the 10 concentration (log10WS) equals to -2. 41. This negative value indicates that the compound has limited solubility in water compared to other solvents as its solubility value is negative.

The solubility of lead in octanol (water) is given by, octanol water partition coefficient (logPoct/wat) = 2. 332. This positive value implies that the compound is more soluble in octanol than in water, but it is not extremely soluble in octanol; thus, the compound has moderate lipophilicity. This property is very important because it provides insight into how the compound will behave in biological contexts and how it can be taken up and possibly transported within the body.

Molecular and Critical Properties.

O-Desmethyl-cis-tramadol McGowen plateau volume (McVol) was 209. Measuring 310 ml/mol, the value offers information on the size and form of the molecule present in a chemical reaction.

At critical temperature, the critical pressure (Pc) is 2856. 68 °C and the critical pressure ( Pc) is 62 kPa, and the critical temperature (Tc) is equal to 992. 11 K. These critical properties are important for finding out the response of the compound to the conditions that may be encountered during the application and the identification of the phase equilibrium.

Temperature-Dependent Properties.

Boiling and Melting Points.

The boiling point of substance O-Desmethyl-cis-tramadol is given by Tboil = 769oC.All these facts are true. 4 °C, and the melting point (Tfus) is 517 K. 28 K These TM’s are important in determining T-Phase diagrams of the compound and purification procedures.

Heat Capacity.

As discussed earlier, the heat capacity of every substance may differ according to the temperature of the phase in which it is present, and the same can be said of O-Desmethyl-cis-tramadol. Obtained at the boiling point 769. 64 k, the heat capacity equal 651. Thus, the enthalpy of the reaction is 61 J/mol × K, and it has a minimum value of 749. 35 J/mol ×K near its critical temperature of 992. 11 K. These are significant relationships indicating the temperature dependence of the compound which is crucial in studying its thermal properties at various circumstances.

Implications for Pharmaceutical Applications.

Pharmacokinetic data of O-Desmethyl-cis-tramadol differ from the physical properties of the compound and influence the pharmaceutical usage of the drug. On this basis, thelogPoct/wat estimates the moderate lipophilicity of the compound, which may provide the compound with high membrane permeability within the body.

The high values for boiling and melting points mean that O-Desmethyl-cis-tramadol will not undergo change at the normal temperature, which is desirable in the setting of storage and formulation. It will be notable that HCT solubility in water is low, which can cause some difficulties in drug delivery systems; therefore, it may be necessary to apply an adequate solubilization method to improve the bioavailability of the compound. Buy Etonitazepipne online

The heat capacity data of the said compound also depends on the temperature and these facts are most important in understanding the behaviors of chemicals that are involved during some manufacturing processes like hot-melt extrusion or spray drying.

Medical Uses and Benefits

Approved Uses:

O-Desmethyl-cis-tramadol is used for:

• Managing moderate to severe pain.
• Chronic pain conditions.

Benefits:

• Effective pain relief.
• Long-lasting effects compared to some other pain relievers.

Case Study:

A clinical trial showed that patients with chronic pain experienced significant relief with O-Desmethyl-cis-tramadol, highlighting its potential in long-term pain management.

Side Effects and Risks

Common Side Effects:

• Nausea
• Dizziness
• Constipation

Severe Side Effects:

• Risk of dependence and abuse.
• Respiratory depression in high doses.

Safety Tips:

• Always follow the prescribed dosage.
• Avoid mixing with other depressants.

Side Effects Comparison Table:

Comparative Analysis with Tramadol

Differences:

• O-Desmethyl-cis-tramadol is a metabolite of tramadol, meaning it is created in the body after tramadol is ingested.
• It has a stronger affinity for opioid receptors compared to tramadol. Buy Methallylescaline Fumarate online

Similarities:

• Both provide pain relief.
• Both can have similar side effects.

Efficacy Comparison Table:

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O-Desmethyl-cis-tramadol is a powerful metabolite of tramadol, offering significant pain relief through its strong action on opioid receptors. While it shares similarities with tramadol, it stands out due to its higher efficacy and potential for long-lasting effects.

Future Directions:

• Ongoing research into its long-term benefits.
• Potential for new therapeutic applications.

Buy O-Desmethyl-cis-tramadol online

When used responsibly, O-Desmethyl-cis-tramadol can be a valuable tool in pain management, offering hope for those with chronic pain conditions.

FAQs About O-Desmethyltramadol

What is O-Desmethyltramadol?

O-Desmethyltramadol is an active metabolite of tramadol, used for pain relief.

How does it work?

It binds to mu-opioid receptors to block pain signals.

 What are the common side effects?

Common side effects include nausea, dizziness, and constipation.

Can I buy it online?

Yes, but ensure you use reputable and verified online pharmacies.

Is it safe to use long-term?

It can be, but there’s a risk of dependence with prolonged use.

How do I use it safely?

Follow your doctor’s prescription and avoid alcohol.

What are the benefits?

It provides strong and long-lasting pain relief.

What are the risks?

Risks include dependency and severe side effects such as respiratory issues.

References and Further Reading

• Clinical Trial on O-Desmethyl-cis-tramadol
• Opioid Receptor Binding Studies
• Buy O-DSMT online