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What is α-Pyrrolidinoisohexanophenone or A-PiHP or α-PiHP | buy A-PiHP online

Discover everything about α-Pyrrolidinoisohexanophenone (A-PiHP) – from its chemical properties to effects and legal status. Buy A-PiHP online from trusted suppliers with worldwide shipping to UK, USA, Germany, Australia and Asia.

🔬 What is α-Pyrrolidinoisohexanophenone (A-PiHP)? 🧪

α-Pyrrolidinoisohexanophenone, commonly known as A-PiHP or α-PiHP, is a synthetic stimulant belonging to the cathinone class. This research chemical has gained significant attention in scientific communities and among researchers studying novel psychoactive substances. As a positional isomer of pyrovalerone, A-PiHP exhibits unique chemical properties that make it valuable for various research applications.

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Chemical Structure and Properties 📊

A-PiHP, with its IUPAC name 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one, belongs to the substituted cathinone and pyrrolidine chemical classes. Its molecular formula is C₁₆H₂₃NO with a molar mass of 245.366 g·mol⁻¹.

The structural uniqueness of A-PiHP lies in its methyl group positioning, transferred from the 4-position of the aromatic ring to the 4-position of the acyl chain. This configuration distinguishes it from other cathinones and contributes to its distinct pharmacological profile.

📜 History and Emergence of A-PiHP 🌍

The emergence of A-PiHP in the research chemical market dates back to July 2016 when it was first identified as a designer drug by a forensic laboratory in Slovenia and reported to the EMCDDA. Since then, its presence has been documented across 30 countries and territories spanning Europe, Asia, North America, and Oceania.

According to recent studies, A-PiHP has become one of the top five synthetic cathinones seized by weight across Europe, highlighting its significance in the current research chemical landscape. The United Nations Office on Drugs and Crime has noted the increasing prevalence of this substance, leading to its placement under international control as a Schedule II controlled substance in March 2023.

“The volume of seized synthetic cathinones in Europe surged significantly between 2021 and 2022, representing about 86% of the total NPS quantity (30.8 tonnes) seized by EU Member States.” – European Monitoring Centre for Drugs and Drug Addiction & Europol, 2024

🔬 Pharmacological Effects and Mechanism of Action ⚗️

A-PiHP functions primarily as a potent norepinephrine-dopamine reuptake inhibitor (NDRI), exhibiting a pharmacological profile similar to other pyrovalerone cathinones. Research indicates that A-PiHP displays a higher selectivity for the dopamine transporter compared to α-PVP and α-PHP, making it particularly interesting for neurochemical research.

Key Pharmacological Characteristics:

• Potent DAT/NET inhibitor: A-PiHP shows in vitro potency similar to α-PVP for the dopamine transporter and slightly lower for the norepinephrine transporter
• Minimal SERT impact: Unlike many other psychoactive substances, A-PiHP has minimal effect on serotonin transporters
• High brain permeability: The lipophilic pyrrolidine ring contributes to excellent blood-brain barrier penetration
• Catecholamine selective: Acts as a selective transporter blocker without substrate-releasing properties

Studies have demonstrated that A-PiHP can induce significant increases in body temperature and locomotor activity, though higher doses (ED50: 4.0 mg/kg) are required compared to α-PVP (ED50: 1.1 mg/kg) to elicit similar effects. This difference is attributed to the approximately 40% lower Cmax levels of A-PiHP in blood and brain.

💊 Administration and Dosage Information 📏

In research settings, A-PiHP is typically administered through various routes depending on the experimental design. Understanding proper administration protocols is crucial for researchers working with this compound.

Common Administration Methods:

1. Oral ingestion: Most common method for research studies
2. Nasal insufflation: Used in specific pharmacokinetic studies
3. Inhalation/vaping: Employed in research examining pulmonary absorption
4. Intravenous administration: Used in controlled laboratory settings
5. Rectal administration: Occasionally utilized in bioavailability studies

Reported research dosages of A-PiHP typically range from 1 to 50 mg, adjusted according to the route of administration and desired experimental outcomes. It’s important to note that these dosages are for research purposes only and should be handled by qualified professionals in controlled laboratory environments.

⚠️ Safety Considerations and Adverse Effects 🚨

When working with A-PiHP in research settings, understanding its safety profile and potential adverse effects is paramount. While comprehensive human safety data is limited, animal studies and case reports provide valuable insights for researchers.

Documented Adverse Effects in Research Settings:

• Cardiovascular effects: Tachycardia, hypertension, vasoconstriction
• Neurological effects: Agitation, hallucinations, delirium
• Thermoregulatory effects: Hyperthermia
• Muscular effects: Tremors, potential rhabdomyolysis
• Psychological effects: Anxiety, paranoia, psychosis

According to the World Health Organization, A-PiHP consumption has been linked to severe poisonings and fatalities in both Europe and the United States. Between January 2020 and June 2021, the US State Unintentional Drug Overdose Reporting System listed A-PiHP as the cause of death in 18 cases.

“Fatalities solely attributed to A-PiHP intoxication showed femoral blood concentrations ranging from 69 to 2377 ng/mL and brain concentrations between 230 and 1506 ng/g.” – Adamowicz et al., 2020

🌐 Legal Status of A-PiHP Worldwide ⚖️

The legal status of A-PiHP varies significantly across different jurisdictions, reflecting evolving regulatory approaches to novel psychoactive substances. Researchers must be aware of these regulations when conducting studies with this compound.

Legal Status by Region:

In March 2023, the United Nations placed A-PiHP under international control as a Schedule II controlled substance, reflecting growing concerns about its potential for abuse and associated health risks. Researchers must ensure compliance with all applicable regulations when working with this compound.

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For researchers seeking high-quality A-PiHP for legitimate scientific studies, finding a reliable supplier is crucial. At Newchemicalz.com, we specialize in providing premium research chemicals to qualified researchers and institutions worldwide.

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When you buy A-PiHP online from us, you’re not just purchasing a chemical – you’re investing in the reliability and consistency of your research outcomes.

🔄 A-PiHP vs. Other Synthetic Cathinones 🔍

Understanding how A-PiHP compares to other synthetic cathinones can help researchers select the most appropriate compounds for their studies. While sharing structural similarities with substances like α-PVP and α-PHP, A-PiHP exhibits distinct characteristics.

Comparative Analysis:

Research indicates that A-PiHP displays lower potency in inducing locomotor activity compared to α-PVP, primarily due to its approximately 40% lower Cmax levels in blood and brain. This pharmacokinetic difference makes A-PiHP particularly interesting for researchers studying structure-activity relationships in synthetic cathinones.

🔬 Research Applications of A-PiHP 🧪

A-PiHP serves as a valuable tool in various research domains, contributing to our understanding of neurochemistry, pharmacology, and substance use disorders. Its unique pharmacological profile makes it particularly useful for specific research applications.

Primary Research Applications:

1. Neurotransmitter Transport Studies: Investigating dopamine and norepinephrine reuptake mechanisms
2. Structure-Activity Relationship Research: Examining how molecular modifications affect pharmacological activity
3. Addiction Research: Studying the neurochemical basis of substance use disorders
4. Toxicological Studies: Understanding the mechanisms of synthetic cathinone toxicity
5. Analytical Method Development: Creating detection and identification protocols for novel psychoactive substances

Researchers at institutions across the UK, USA, Germany, Australia, and Asia have utilized A-PiHP to advance our understanding of cathinone pharmacology and its implications for public health.

❓ Frequently Asked Questions About A-PiHP ❓

1. What is the difference between A-PiHP and α-PVP? 🤔

A-PiHP and α-PVP are both synthetic cathinones, but they differ in their chemical structure. A-PiHP has an additional methyl group forming an isobutyl group on the α-carbon chain, while α-PVP does not. This structural difference results in A-PiHP having approximately 40% lower Cmax levels in blood and brain, making it less potent in inducing locomotor activity compared to α-PVP. However, both compounds exhibit similar in vitro potency as dopamine and norepinephrine reuptake inhibitors.

2. Is A-PiHP legal for research purposes? ⚖️

The legal status of A-PiHP varies by country. In the UK, it’s classified as a Class B controlled substance. In Germany, it’s listed under Anlage II, allowing authorized trade but not prescription. The United Nations has placed A-PiHP under international control as a Schedule II controlled substance since March 2023. Researchers must ensure compliance with all applicable regulations in their jurisdiction before working with this compound. Always check current regulations before purchasing A-PiHP for research purposes.

3. How should A-PiHP be stored for research purposes? 📦

For optimal stability and preservation of chemical integrity, A-PiHP should be stored at -20°C in a cool, dry place away from direct sunlight. The compound is stable for at least two years when stored under these conditions. When handling A-PiHP, researchers should use appropriate personal protective equipment, including gloves, lab coats, and eye protection, and work in a well-ventilated area or fume hood to minimize exposure risks.

4. What are the common research applications of A-PiHP? 🔬

A-PiHP is primarily used in neuroscience and pharmacology research to study dopamine and norepinephrine transporter function, investigate the structure-activity relationships of synthetic cathinones, and examine the neurochemical basis of substance use disorders. It’s also valuable in toxicological studies aimed at understanding the mechanisms of synthetic cathinone toxicity and in analytical research developing detection methods for novel psychoactive substances.

5. Where can I buy high-quality A-PiHP for research? 🛒

High-quality A-PiHP for legitimate research purposes can be purchased from specialized chemical suppliers like Newchemicalz.com. When selecting a supplier, consider factors such as purity (minimum 98.0%), quality control testing, shipping options to your location, and technical support availability. Always ensure you’re purchasing from a reputable supplier that complies with all applicable regulations and provides proper documentation for research purposes.

6. What safety precautions should be taken when working with A-PiHP? ⚠️

When working with A-PiHP in research settings, researchers should implement comprehensive safety protocols. These include working in a controlled laboratory environment with proper ventilation, using appropriate personal protective equipment (gloves, lab coat, eye protection), implementing spill containment procedures, and having emergency protocols in place. Due to its potency and potential health risks, A-PiHP should only be handled by trained researchers familiar with its properties and risks.

7. How does A-PiHP compare to other research chemicals in terms of research value? 📊

A-PiHP offers unique research value due to its distinct pharmacological profile, particularly its higher selectivity for the dopamine transporter compared to similar compounds. Its structural relationship to other cathinones makes it valuable for structure-activity relationship studies. Additionally, its increasing prevalence in seized materials worldwide makes it important for forensic and epidemiological research. While many research chemicals have limited applications, A-PiHP’s unique properties make it particularly valuable for neuroscience and pharmacology research.

🎯 Key Takeaways About A-PiHP 📝

• A-PiHP is a synthetic cathinone with the chemical name 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one
• It functions primarily as a norepinephrine-dopamine reuptake inhibitor with high selectivity for the dopamine transporter
• First identified in 2016, A-PiHP has become one of the top five synthetic cathinones seized by weight in Europe
• The compound has been linked to serious health risks including cardiovascular effects, hyperthermia, and neurological symptoms
• Legal status varies by country, with international control established under UN Schedule II in March 2023
• For research purposes, A-PiHP should be stored at -20°C and handled with appropriate safety precautions
• When purchasing A-PiHP, researchers should select suppliers offering minimum 98.0% purity with comprehensive quality control

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🔬 Explore More Research Chemicals 🔬

In addition to A-PiHP, we offer a comprehensive range of research chemicals for various scientific applications. Explore our other products to find the perfect compounds for your research:

• 3-FPM: A novel stimulant for neuroscience research
• 2-FDCK: A dissociative anesthetic for pharmacological studies
• 3-MMC Crystal: A popular cathinone derivative for research
• 4-EMC: A valuable tool for neurochemical research
• MDPHP: A potent stimulant for neuroscience applications

For more information about our products and services, visit our research chemicals category or explore our blog for the latest insights in research chemistry.

Disclaimer: This article is for informational purposes only. A-PiHP is intended for research purposes only and should only be handled by qualified professionals in controlled laboratory environments. Always comply with all applicable laws and regulations in your jurisdiction. The information provided does not constitute medical or legal advice.