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🧪 What is 4-HO-MET | Buy 4-HO-MET Online | 4-HO-MET for Sale 🧪 The Psychedelic Tryptamine

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4-HO-MET, also known as 4-hydroxy-N-methyl-N-ethyltryptamine or metocin, belongs to the tryptamine family of psychedelic compounds. As a close structural analogue of psilocin (the active compound in magic mushrooms), this substance has garnered significant interest in the research community for its unique properties and potential applications.

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🔬 What is 4-HO-MET?

4-HO-MET is a synthetic psychedelic compound of the tryptamine class, first synthesized by the renowned chemist Alexander Shulgin in the 1970s. This compound is structurally related to psilocin, with the key difference being the substitution of a methyl group with an ethyl group on the nitrogen atom.

The chemical formula of 4-HO-MET is C₁₃H₁₈N₂O, with a molar mass of 218.300 g·mol⁻¹. It appears as a white to off-white crystalline powder at room temperature and is soluble in various solvents, making it suitable for different research applications.

Chemical Properties of 4-HO-MET

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🌈 The Effects and Experience of 4-HO-MET

Understanding the effects of 4-HO-MET is crucial for researchers studying its potential applications. Based on user reports and scientific studies, this compound produces a range of psychoactive effects similar to other classic psychedelics, but with some unique characteristics.

Primary Effects of 4-HO-MET

Mydriasis (pupil dilation) is one of the first noticeable physical effects, often accompanied by a sense of euphoria and tingling sensations throughout the body. Users frequently report perceptual changes, including both closed-eye and open-eye visuals, which can range from mild pattern distortions to complex geometric hallucinations.

One of the most distinctive aspects of the 4-HO-MET experience is its clear-headed nature compared to other psychedelics. Many users describe it as producing strong visual effects while maintaining mental clarity and functionality, similar to the relationship between 2C-B and other phenethylamines.

Subjective Experience Reports

According to phenomenological studies of recreational use, the 4-HO-MET experience includes:

• Visual Effects: Enhanced colors, patterns, and geometric visuals
• Synesthesia: Blending of senses, such as “seeing” sounds or “hearing” colors
• Time Dilation: Altered perception of time, often feeling slower
• Emotional Effects: Increased empathy, euphoria, and emotional sensitivity
• Cognitive Effects: Altered thought patterns, increased creativity, and introspection

The effects typically begin within 20-40 minutes of oral administration, peak around 2-3 hours, and gradually subside over the next 2-3 hours, for a total duration of approximately 4-6 hours.

Comparison with Psilocin

As a close analogue of psilocin, 4-HO-MET produces similar effects but with some notable differences. While both compounds activate serotonin receptors, particularly the 5-HT₂A receptor, users often report that 4-HO-MET provides a more controlled and less overwhelming experience, making it an interesting subject for comparative studies.

📊 Dosage Information for Research Purposes

When conducting research with 4-HO-MET, accurate dosage is critical for consistent results and safety. Based on the available literature and user reports, we can establish some general dosage guidelines for research purposes.

Recommended Dosage Range

Alexander Shulgin, in his book TiHKAL (Tryptamines I Have Known and Loved), initially listed the dosage range as 10-20 mg orally. However, subsequent recreational use reports have indicated a wider range of 2-45 mg, with 15 mg being a commonly cited moderate dose.

Factors Affecting Dosage

Several factors can influence the appropriate dosage of 4-HO-MET for research:

• Body Weight: Heavier individuals may require higher doses
• Tolerance: Previous exposure to psychedelics can affect sensitivity
• Set and Setting: Environmental factors can influence the experience
• Individual Sensitivity: Natural variations in metabolism and receptor density

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⚖️ Legal Status of 4-HO-MET Around the World

Understanding the legal status of 4-HO-MET is essential for researchers and enthusiasts. The legal landscape varies significantly between countries, and staying informed about current regulations is crucial.

Legal Status by Country

United States Specifics

In the United States, 4-HO-MET is not scheduled at the federal level, but it could be considered an analogue of psilocin under the Federal Analogue Act. This means that purchase, sale, or possession could potentially be prosecuted if intended for human consumption. Additionally, some states have scheduled 4-HO-MET as a Schedule I controlled substance, including South Dakota and West Virginia.

European Union Regulations

Within the European Union, the legal status of 4-HO-MET varies by member state. Germany has implemented specific controls under the NpSG, while the United Kingdom classifies it as a Class A drug. Sweden and Finland have also implemented strict controls on this compound.

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🔬 Pharmacology of 4-HO-MET: Mechanism of Action

The pharmacological profile of 4-HO-MET is fascinating and provides insight into its psychoactive effects. Understanding how this compound interacts with the brain’s receptor systems is crucial for researchers studying its potential applications.

Receptor Binding Profile

4-HO-MET primarily acts as a serotonin receptor agonist, with particular affinity for the 5-HT₂A receptor, which is believed to be primarily responsible for its hallucinogenic effects. The compound’s binding affinity for various receptors has been studied, revealing a complex pharmacological profile.

Metabolism and Pharmacokinetics

The metabolism of 4-HO-MET has been studied in vitro and in vivo, revealing several metabolic pathways. Like other tryptamines, it undergoes deamination, oxidation, and conjugation processes in the body.

The primary metabolic pathways include:

• Deamination: Removal of the amino group
• Oxidation: Conversion to inactive metabolites
• Glucuronidation: Conjugation with glucuronic acid for excretion

The duration of action of 4-HO-MET is typically 4-6 hours, with effects beginning within 20-40 minutes of oral administration and peaking around 2-3 hours.

Neuropharmacological Effects

The activation of serotonin receptors, particularly 5-HT₂A, leads to increased glutamate release in the cortex, which is believed to underlie the psychedelic effects of 4-HO-MET. This cascade of neurochemical events results in altered perception, mood, and cognition.

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⚠️ Safety Considerations and Harm Reduction

While 4-HO-MET is generally considered to have a favorable safety profile compared to many other psychoactive substances, it’s essential to approach research with proper safety protocols and harm reduction strategies.

Physical Safety Considerations

4-HO-MET may cause several physiological effects that researchers should be aware of:

• Cardiovascular Effects: Increased heart rate and blood pressure
• Pupil Dilation: Mydriasis lasting several hours
• Body Temperature: Slight increases in core temperature
• Nausea: Mild gastrointestinal discomfort in some cases

Studies have suggested that 4-HO-MET might have adverse effects on the cardiovascular system, particularly at higher doses. Researchers should monitor cardiovascular parameters when studying this compound.

Psychological Safety Considerations

The psychological effects of 4-HO-MET can be intense and may pose risks for certain individuals:

• Psychological Vulnerability: Not recommended for individuals with pre-existing psychological conditions
• Thought Loops: Potential for repetitive or circular thinking patterns
• Perceptual Distortions: Altered sense of time, space, and distance
• Emotional Intensity: Amplification of emotions, both positive and negative

According to research, 4-HO-MET is not recommended for people already suffering from psychological and emotional problems, as using it may enhance these conditions, and the effects of coming down may last longer.

Harm Reduction Strategies

For researchers studying 4-HO-MET, the following harm reduction strategies are recommended:

1. Start with Low Doses: Begin with the minimum effective dose to assess sensitivity
2. Controlled Environment: Conduct research in a safe, comfortable setting
3. Trip Sitter: Have a sober individual present to monitor the experience
4. Medical Screening: Ensure participants are physically and psychologically healthy
5. Avoid Mixing: Do not combine with other substances, especially MAOIs or stimulants

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🛒 How to Buy 4-HO-MET Online: A Complete Guide

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❓ Frequently Asked Questions About 4-HO-MET

We’ve compiled answers to the most frequently asked questions about 4-HO-MET to help researchers make informed decisions.

What is 4-HO-MET and how does it differ from psilocin?

4-HO-MET, also known as 4-hydroxy-N-methyl-N-ethyltryptamine or metocin, is a synthetic psychedelic compound of the tryptamine family. It’s closely related to psilocin (4-HO-DMT), with the primary difference being the substitution of a methyl group with an ethyl group on the nitrogen atom. This subtle structural change results in some differences in effects, with many users reporting that 4-HO-MET produces a more clear-headed experience while still maintaining strong visual effects. The duration of action is similar, typically lasting 4-6 hours.

Is it legal to buy 4-HO-MET online in my country?

The legal status of 4-HO-MET varies by country. In the United Kingdom, it’s classified as a Class A drug under the tryptamine catch-all clause. In the United States, it’s not federally scheduled but could be prosecuted under the Federal Analogue Act as a psilocin analogue. Germany has implemented controls under the NpSG, while Australia lists it as a Schedule 9 prohibited substance. Sweden and Finland have also implemented strict controls. Before you buy 4-HO-MET online, it’s essential to research and understand the specific regulations in your jurisdiction.

What is the recommended dosage for research with 4-HO-MET?

For research purposes, the dosage of 4-HO-MET typically ranges from 2-45 mg, depending on the desired intensity of effects. Alexander Shulgin initially recommended 10-20 mg in his book TiHKAL, but subsequent reports have indicated a wider effective range. A moderate dose is generally considered to be around 15 mg. When conducting research, it’s advisable to start with lower doses and gradually increase as needed, while carefully monitoring all effects and parameters.

How should 4-HO-MET be stored for maximum stability?

4-HO-MET should be stored in a cool, dry place away from direct sunlight and moisture. For long-term storage, keeping it in an airtight container in a refrigerator or freezer can help maintain stability and potency. The compound is sensitive to oxidation, so minimizing exposure to air is important. When you buy 4-HO-MET online from Newchemicalz.com, we provide detailed storage instructions to ensure your research material remains stable throughout your study period.

What safety precautions should be taken when researching 4-HO-MET?

When researching 4-HO-MET, several safety precautions should be observed:

• Always use proper personal protective equipment (PPE) when handling the compound
• Start with low doses to assess sensitivity and effects
• Conduct research in a controlled, safe environment
• Have emergency protocols in place
• Avoid combining with other substances, especially MAOIs
• Screen participants for pre-existing psychological conditions
• Monitor cardiovascular parameters during research
• Keep detailed records of all procedures and observations

How does 4-HO-MET compare to other psychedelic tryptamines?

4-HO-MET is often compared to other psychedelic tryptamines like psilocin, 4-AcO-DMT, and 4-HO-MiPT. While all these compounds share a similar core structure and mechanism of action, they produce distinct subjective effects. 4-HO-MET is frequently described as producing strong visual effects while maintaining more mental clarity compared to psilocin. It’s often considered more visual than 4-HO-MiPT but less introspective than 4-AcO-DMT. These subtle differences make it an interesting compound for comparative research in psychedelic studies.

Can 4-HO-MET be detected in drug tests?

Standard drug tests typically do not screen for 4-HO-MET specifically. However, it may be detected as part of broader tryptamine or psychedelic panels in specialized testing. The compound’s metabolites can be identified in urine, blood, and hair samples using advanced analytical techniques like gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). The detection window varies depending on the sample type, frequency of use, and individual metabolism, but generally ranges from 1-3 days in urine and up to 90 days in hair samples.

🎯 Key Takeaways About 4-HO-MET

As we conclude our comprehensive overview of 4-HO-MET, let’s summarize the key points that researchers should keep in mind:

• Chemical Identity: 4-HO-MET is 4-hydroxy-N-methyl-N-ethyltryptamine, a synthetic psychedelic tryptamine closely related to psilocin
• Effects Profile: Produces visual hallucinations, altered perception, and cognitive effects while maintaining relative mental clarity
• Dosage Range: Effective doses typically range from 2-45 mg, with 15 mg being a common moderate dose
• Duration: Effects last approximately 4-6 hours, beginning within 20-40 minutes of administration
• Legal Status: Varies by country, with controls in place in the UK, US, Germany, Australia, Sweden, and Finland
• Safety Considerations: Generally considered to have a favorable safety profile, but precautions are necessary, especially for individuals with psychological vulnerabilities
• Research Applications: Valuable for studying serotonin receptor function, psychedelic therapy, and consciousness research

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